Findings

What do systematic reviews say?

8 questions · 8 findings · 5 reviews · Oral and maxillofacial surgery

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 7 · 87.5%Very low 1 · 12.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
Weekly (to 16 weeks)
no estimate extracted
1 study · 42 participants
GRADE not reported

Plasma rich in growth factors (PRGF) vs Alvogyl

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Plasma rich in growth factors (PRGF) showed no clear difference in pain (VAS cm) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Day 7 (also day 3)
MD -0.40 [-1.77, 0.97]
1 study · 44 participants
GRADE not reported

Advanced platelet rich fibrin (A-PRF) vs No active treatment (control)

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Days 1-7 (day 7 shown)
MD -3.60 [-4.00, -3.20]
1 study · 40 participants
GRADE not reported

Piezoelectric bone removal vs Conventional rotary handpiece

Postoperative pain (mean) · Adults with mandibular third molars requiring removal

Piezoelectric bone removal led to lower postoperative pain (mean) compared with conventional rotary handpiece; GRADE not reported.

1 finding from 1 review

Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes
24 hours · piezoelectric vs conventional
MD -1.93 [-3.08, -0.77]
5 studies · 111 participants
GRADE not reported

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

Adverse effects (wound pain) · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
2 weeks to 12 months
This comparison was only made in 1 study: mean pain scores at 2 weeks, 2, 6, 9, and 12 months showed no 'significant' differences between the 2 groups (self-reported Likert scale 1 to 10; difference at 2 weeks P =…
1 study · 44 participants
Very low

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous TMJ pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
15 days
MD -0.90 [-1.35, -0.45]
1 study · 52 participants
GRADE not reported

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous masseter muscle pain (numerical graph rating scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous masseter muscle pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
15 days
MD -2.00 [-2.38, -1.62]
1 study · 52 participants
GRADE not reported

Alvogyl vs Platelet-rich fibrin (PRF)

Pain · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Alvogyl versus platelet rich fibrin (Keshini 2020): single study (30 participants); no usable pooled estimate extracted
1 study · 30 participants
GRADE not reported