What do systematic reviews say?

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

TMD and TMJ arthritis/involvement (and orofacial pain) were consistently reported more frequently in children/adolescents with JIA than in healthy peers, though several studies had small samples; no pooled estimate (ungraded).

• Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis. 2019 All outcomes

  Latvia, Egypt, Sweden and United Kingdom (Al-Shwaikh 2016, Abdul-Aziez 2010, Mohammed 2012, Leksell 2012, Ahmed 2004)
  TMJ arthritis, TMJ involvement and TMD were coherently reported more frequently among children with JIA than healthy peers [35-38] (TMJ dysfunction also in [22]); e.g., higher frequency of condylar surface flattening…
  5 studies · 367 participants
  GRADE not reported

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

The review found no eligible studies for this question.

• Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate vs alternative disease‐modifying antirheumatic drugs

The review found no eligible studies for this question.

• Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Custom foot orthoses vs shoes

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Methotrexate vs placebo

• Methotrexate for juvenile idiopathic arthritis 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 114 participants
  Low