Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapyPVR · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 303 participantsHigh
Group 1 Pulmonary arterial hypertension ‐ PDE5i vs ERAPVR · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 11 participantsLow
Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placeboPVR · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 266 participantsHigh
Group 3 Pulmonary hypertension due to lung disease ‐ PDE5i vs placeboPVR · people with pulmonary hypertension due to lung disease1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 28 participantsLow
Group 4 Pulmonary hypertension due to CTEPH ‐ PDE5i vs placeboPVR · people with pulmonary hypertension due to CTEPH2 findings from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 19 participantsLowPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 227 participantsModerate
Selexipag vs placeboPVR · pulmonary arterial hypertension1 finding from 1 reviewProstacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 43 participantsModerate
Prostacyclin vs controlPVR · pulmonary arterial hypertension1 finding from 1 reviewProstacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 658 participantsModerate
Endothelin receptor antagonists vs placeboChange from baseline in PVR (dyn/s/cm5) mean duration of study 15.7 weeks · pulmonary arterial hypertension1 finding from 1 reviewEndothelin receptor antagonists for pulmonary arterial hypertension 2021 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 586 participantsModerate