Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapyPAP · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 387 participantsHigh
Group 1 Pulmonary arterial hypertension ‐ PDE5i vs ERAPAP · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 11 participantsLow
Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placeboPAP · pulmonary arterial hypertension1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted6 studies · 453 participantsModerate
Group 3 Pulmonary hypertension due to lung disease ‐ PDE5i vs placeboPAP · people with pulmonary hypertension due to lung disease1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 61 participantsModerate
Group 2 Pulmonary hypertension due to left‐heart disease ‐ PDE5i vs placeboPAP · people with pulmonary hypertension due to left‐heart disease1 finding from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 130 participantsModerate
Group 4 Pulmonary hypertension due to CTEPH ‐ PDE5i vs placeboPAP · people with pulmonary hypertension due to CTEPH2 findings from 1 reviewPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 19 participantsLowPhosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 227 participantsModerate
Selexipag vs placebomPAP (the higher the mPAP, the worse the pulmonary hypertension) · pulmonary arterial hypertension1 finding from 1 reviewProstacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 43 participantsModerate
Prostacyclin vs controlmPAP (the higher the mPAP, the worse the pulmonary hypertension) · pulmonary arterial hypertension1 finding from 1 reviewProstacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes onlyno estimate extracted8 studies · 1132 participantsLow
Exercise vs controlCardiopulmonary haemodynamics (mPAP) mmHg · people with pulmonary hypertension1 finding from 1 reviewExercise‐based rehabilitation programmes for pulmonary hypertension 2023 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 133 participantsLow
Endothelin receptor antagonists vs placeboChange from baseline in mean PAP (mmHg) mean duration of study 17.1 weeks · pulmonary arterial hypertension1 finding from 1 reviewEndothelin receptor antagonists for pulmonary arterial hypertension 2021 · Cochrane Headline outcomes onlyno estimate extracted8 studies · 729 participantsModerate