Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Infectious Diseases

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 1 · 16.7%Moderate 2 · 33.3%High 2 · 33.3%

Primaquine five days vs 14 days

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

Primaquine five days probably leads to higher P. vivax parasitaemia detected > 30 days after starting primaquine compared with 14 days (moderate certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 10.05 [2.82, 35.86]
2 studies · 186 participants
Moderate

Primaquine three days vs 14 days

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

Primaquine three days probably leads to higher P. vivax parasitaemia detected > 30 days after starting primaquine compared with 14 days (moderate certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 3.18 [2.1, 4.81]
2 studies · 262 participants
Moderate

Primaquine seven days vs 14 days

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

Primaquine seven days may leads to higher P. vivax parasitaemia detected > 30 days after starting primaquine compared with 14 days (low certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 2.24 [1.24, 4.03]
1 study · 126 participants
Low

Primaquine (weekly for eight weeks) vs daily primaquine

P. vivax parasitaemia detected > 30 days after starting primaquine · Children and adults with blood smear positive P. vivax malaria1

It is very uncertain whether primaquine (weekly for eight weeks) changes P. vivax parasitaemia detected > 30 days after starting primaquine compared with daily primaquine (very low certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 2.97 [0.34, 25.87]
1 study · 129 participants
Very low

Intervention not reported

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

The intervention showed no clear difference in P. vivax parasitaemia detected > 30 days after starting primaquine (high certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 0.98 [0.73, 1.3]
4 studies · 2213 participants
High

Intervention not reported

P. vivax parasitaemia detected > 30 days after starting primaquine · People with P. vivax malaria1

The intervention leads to lower P. vivax parasitaemia detected > 30 days after starting primaquine (high certainty).

1 finding from 1 review

Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine 2013 · Cochrane Headline outcomes only
RR 0.6 [0.48, 0.75]
10 studies · 1740 participants
High