Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 2 reviews · Haematology

No studies found 7 · 63.6%GRADE not reported 0 · 0%Very low 1 · 9.1%Low 2 · 18.2%Moderate 1 · 9.1%High 0 · 0%

Heparin vs no treatment

Overall survival ( · People undergoing autologous or HLA identical allogeneic bone marrow transplant with a variety of malignant diseases or aplastic anaemia

It is very uncertain whether summary of findings: Heparin changes overall survival ( compared with no treatment (very low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

Overall survival ( · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in overall survival ( compared with no treatment (low certainty).

1 finding from 1 review

Ursodeoxycholic acid vs placebo or no treatment

Overall survival ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid showed no clear difference in overall survival ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ Daratumumab plus standard therapy vs usual care

Overall survival (at 36 months) · people with newly diagnosed multiple myeloma ineligible for transplant

Summary of findings table ‐ Daratumumab plus standard therapy probably leads to lower overall survival (at 36 months) compared with standard therapy (moderate certainty).

1 finding from 1 review