Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Childhood Cancer

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No studies found 2 · 66.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Continuous platinum infusion vs bolus platinum infusion

Overall survival ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
HR 0.43 [0.03, 5.85]
1 study · 109 participants
Low

Amifostine vs no otoprotective intervention

Survival (overall and event‐free) ‐ not reported · children with cancer treated with platinum‐based therapy

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found