Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 66.7%High 1 · 33.3%

Overall survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy leads to lower overall survival compared with placebo, best supportive care (BSC) or no treatment (high certainty).

1 finding from 1 review

Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
HR 0.55 [0.41, 0.73]
3 studies · 781 participants
High

Overall survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemmotherapy combined with biological therapy showed no clear difference in overall survival compared with chemotherapy (moderate certainty).

1 finding from 1 review

Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
HR 0.93 [0.83, 1.04]
7 studies · 2743 participants
Moderate

Overall survival · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy showed no clear difference in overall survival compared with biological therapy (moderate certainty).

1 finding from 1 review

Salvage systemic therapy for advanced gastric and oesophago‐gastric junction adenocarcinoma 2020 · Cochrane Headline outcomes only
HR 0.82 [0.66, 1.02]
1 study · 395 participants
Moderate