Intervention not reported
Other adverse events · infantile‐onset Pompe disease
1 finding from 1 review
- no estimate extracted1 study · 18 participantsLow
Search
What do systematic reviews say?
3 questions · 3 findings · 3 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%
Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)
Side effects or other adverse events · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… showed no clear difference in side effects or other adverse events compared with placebo, no intervention or usual care (with or without placebo) (low certainty).
1 finding from 1 review
- Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomesUp to 10 days postoperativeRD 0.034 [-0.32, 0.38]2 studies · 59 participantsLow
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash
Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).
1 finding from 1 review
- Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes7 daysRD 0.00 [-0.04, 0.04]2 studies · 128 participantsModerate