Findings

What do systematic reviews say?

4 questions · 8 findings · 2 reviews · Oral medicine and oral cancer

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 2 · 25%Very low 2 · 25%Low 1 · 12.5%Moderate 3 · 37.5%High 0 · 0%

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (severe) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… probably leads to lower oral mucositis (severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (moderate certainty).

3 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
High-dose melphalan-based treatment prior to HSCT (haematological cancers)
RR 0.38 [0.20, 0.72]
5 studies · 270 participants
Moderate
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Low-dose methotrexate for GVHD prophylaxis after allogeneic HSCT
RR 0.88 [0.61, 1.25]
1 study · 122 participants
Very low
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Fluorouracil (5FU) treatment for solid cancers
RR 0.40 [0.27, 0.61]
5 studies · 444 participants
Moderate

Indigo wood root vs saline placebo

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Indigo wood root led to lower oral mucositis (severe) compared with saline (placebo); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.14 [0.02, 0.93]
1 study · 20 participants
GRADE not reported

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (moderate to severe) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (moderate to severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).

3 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
High-dose melphalan-based treatment prior to HSCT (haematological cancers)
RR 0.43 [0.17, 1.09]
5 studies · 270 participants
Low
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Low-dose methotrexate for GVHD prophylaxis after allogeneic HSCT
RR 1.01 [0.85, 1.20]
1 study · 122 participants
Very low
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Fluorouracil (5FU) treatment for solid cancers
RR 0.52 [0.41, 0.65]
5 studies · 444 participants
Moderate

Indigo wood root vs saline placebo

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Indigo wood root showed no clear difference in oral mucositis (moderate to severe) compared with saline (placebo); GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.75 [0.5, 1.1]
1 study · 20 participants
GRADE not reported