Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

69 questions · 69 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 64 · 92.8%Very low 1 · 1.4%Low 3 · 4.3%Moderate 1 · 1.4%High 0 · 0%

Oral care protocol vs usual care or no treatment

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Keratinocyte GF 50 mg vs Keratinocyte GF 25 mg

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Keratinocyte GF 50 mg showed no clear difference in oral mucositis (severe) compared with keratinocyte GF 25 mg; GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Chinese herbal medicines vs Control (Dobell's solution)

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chinese herbs (medicine) showed no clear difference in oral mucositis (severe) compared with control (Dobell's solution); GRADE not reported.

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash vs Sucralfate mouthwash

Oral mucositis (moderate to severe) · Adults receiving radiotherapy to the head and neck

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in oral mucositis (moderate to severe) compared with sucralfate mouthwash; GRADE not reported.

1 finding from 1 review

Indigo wood root vs saline placebo

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Indigo wood root showed no clear difference in oral mucositis (moderate to severe) compared with saline (placebo); GRADE not reported.

1 finding from 1 review