Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)
Oral mucositis (moderate to severe) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (moderate to severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).
3 findings from 1 review
- Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomesHigh-dose melphalan-based treatment prior to HSCT (haematological cancers)RR 0.43 [0.17, 1.09]5 studies · 270 participantsLow
- Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomesLow-dose methotrexate for GVHD prophylaxis after allogeneic HSCTRR 1.01 [0.85, 1.20]1 study · 122 participantsVery low
- Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomesFluorouracil (5FU) treatment for solid cancersRR 0.52 [0.41, 0.65]5 studies · 444 participantsModerate