Findings

What do systematic reviews say?

4 questions · 6 findings · 2 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 1 · 16.7%Low 1 · 16.7%Moderate 2 · 33.3%High 0 · 0%

Oral care protocol vs usual care or no treatment

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol led to lower oral mucositis (any severity) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.62 [0.43, 0.91]
1 study · 30 participants
GRADE not reported

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (any severity) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (any severity) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).

3 findings from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
High-dose melphalan-based treatment prior to HSCT (haematological cancers)
RR 0.59 [0.35, 1.01]
5 studies · 270 participants
Low
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Fluorouracil (5FU) treatment for solid cancers
RR 0.61 [0.52, 0.72]
5 studies · 444 participants
Moderate
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
Low-dose methotrexate for GVHD prophylaxis after allogeneic HSCT
RR 0.98 [0.90, 1.07]
1 study · 122 participants
Very low

Sucralfate vs placebo or usual care

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Sucralfate showed no clear difference in oral mucositis (any severity) compared with placebo/usual care (moderate certainty).

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.98 [0.88, 1.1]
3 studies · 222 participants
Moderate

Glutamine vs placebo or usual care

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Glutamine showed no clear difference in oral mucositis (any severity) compared with placebo/usual care; GRADE not reported.

1 finding from 1 review

Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes
Median 28 days
RR 0.78 [0.57, 1.08]
5 studies
GRADE not reported