What do systematic reviews say?

GM-CSF vs placebo/no treatment

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  no estimate extracted
  8 studies
  GRADE not reported

Honey vs no treatment

Honey led to lower oral mucositis (any severity) compared with no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.7 [0.56, 0.88]
  3 studies
  GRADE not reported

Antibiotic pastille or paste (PTA) vs placebo

Antibiotic pastille or paste (PTA) led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.87 [0.78, 0.96]
  2 studies · 356 participants
  GRADE not reported

Chewing gum vs No chewing gum

Chewing gum showed no clear difference in oral mucositis (any severity) compared with no chewing gum; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.87 [0.71, 1.07]
  1 study · 140 participants
  GRADE not reported

Oral care protocol vs usual care or no treatment

Oral care protocol led to lower oral mucositis (any severity) compared with no treatment/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.62 [0.43, 0.91]
  1 study · 30 participants
  GRADE not reported

Keratinocyte GF vs placebo

Keratinocyte GF may leads to lower oral mucositis (any severity) compared with placebo (low certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.82 [0.71, 0.94]
  2 studies · 160 participants
  Low

Acyclovir vs placebo

Acyclovir showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.33 [0.85, 2.08]
  1 study · 57 participants
  GRADE not reported

Superoxide dismutase (SOD) vs placebo

Superoxide dismutase showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.17 [0.78, 1.75]
  1 study · 159 participants
  GRADE not reported

Chinese herbal medicines vs Control (Dobell's solution)

Chinese herbs (medicine) led to lower oral mucositis (any severity) compared with control (Dobell's solution); GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.44 [0.2, 0.95]
  1 study · 147 participants
  GRADE not reported