Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Headline outcomes only

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No studies found 2 · 50%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 2.78 [1.5, 5.16]
2 studies · 614 participants
Low

Tramadol in combination with acetaminophen vs NSAIDs

Withdrawals due to adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol in combination with acetaminophen vs other opioids

Withdrawals due to adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tramadol vs paracetamol

Withdrawals due to adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants who withdrew due to adverse events compared with acetaminophen (very low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 5 [0.27, 92.62]
1 study · 20 participants
Very low