Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Neuromuscular

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Has died · people with TTR‐FAP

It is very uncertain whether diflunisal changes number of participants who died during the trial compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
RR 0.46 [0.15, 1.41]
1 study · 130 participants
Very low

Has died · people with TTR‐FAP

Patisiran showed no clear difference in number of participants who died during the trial compared with placebo (low certainty).

1 finding from 1 review

Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
RR 0.61 [0.21, 1.74]
1 study · 225 participants
Low

Has died · people with TTR‐FAP

Inotersen showed no clear difference in number of participants who died during the trial compared with placebo (low certainty).

1 finding from 1 review

Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
RR 5.94 [0.33, 105.6]
1 study · 172 participants
Low

Has died · people with early‐stage TTR‐FAP

It is very uncertain whether tafamidis changes number of participants who died during the trial compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
RR 0.65 [0.11, 3.74]
1 study · 128 participants
Very low