Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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Oral or transdermal opioids vs placebo

Adverse events as N of participants with at least one adverse event objective · Patients with osteoarthritis of the knee or hip

Oral or transdermal opioids probably leads to higher number of participants experiencing any adverse event (median compared with placebo (moderate certainty).

1 finding from 1 review

Oral or transdermal opioids for osteoarthritis of the knee or hip 2014 · Cochrane Headline outcomes only
RR 1.49 [1.35, 1.63]
9 studies · 4898 participants
Moderate

Oral or transdermal opioids vs placebo

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Oral or transdermal opioids showed no clear difference in number of participants experiencing any serious adverse event (median compared with placebo (low certainty).

1 finding from 1 review

Oral or transdermal opioids for osteoarthritis of the knee or hip 2014 · Cochrane Headline outcomes only
RR 3.35 [0.83, 13.56]
3 studies · 681 participants
Low