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What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 8 findings · 1 reviews · Musculoskeletal

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No studies found 4 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 37.5%Moderate 1 · 12.5%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol vs paracetamol

Number of participants reporting an adverse event · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs paracetamol

Number of participants experiencing any serious adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review