Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib for osteoarthritis 2017 · Cochrane Headline outcomes only
Peto OR 0.92 [0.66, 1.28]
5 studies · 2404 participants
Very low

Tramadol vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 0.21 [0.01, 4.34]
2 studies · 188 participants
Very low

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Low