Findings

What do systematic reviews say?

9 questions · 9 findings · 1 reviews

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No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 7 · 77.8%Moderate 1 · 11.1%High 0 · 0%

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Nosocomial pneumonia · people admitted to intensive care units

Proton pump inhibitors showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.24 [0.77, 1.98]
2 studies · 227 participants
Low

Interventions vs placebo or no prophylaxis

Nosocomial pneumonia · people admitted to intensive care units

Interventions showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.15 [0.9, 1.48]
9 studies · 1331 participants
Low

Antacids vs placebo or no prophylaxis

Nosocomial pneumonia · people admitted to intensive care units

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sucralfate vs placebo or no prophylaxis

Nosocomial pneumonia · people admitted to intensive care units

Sucralfate showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.33 [0.86, 2.04]
4 studies · 450 participants
Low

H2 receptor antagonists vs proton pump inhibitors

Nosocomial pneumonia · people admitted to intensive care units

H2 receptor antagonists showed no clear difference in nosocomial pneumonia compared with proton pump inhibitors (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.02 [0.77, 1.35]
10 studies · 1256 participants
Low

H2 receptor antagonists vs antacids

Nosocomial pneumonia · people admitted to intensive care units

H2 receptor antagonists showed no clear difference in nosocomial pneumonia compared with antacids (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.05 [0.81, 1.36]
4 studies · 581 participants
Low

H2 receptor antagonists vs sucralfate

Nosocomial pneumonia · people admitted to intensive care units

H2 receptor antagonists probably leads to higher nosocomial pneumonia compared with sucralfate (moderate certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.22 [1.07, 1.4]
17 studies · 3041 participants
Moderate

Antacids vs sucralfate

Nosocomial pneumonia · people admitted to intensive care units

Antacids showed no clear difference in nosocomial pneumonia compared with sucralfate (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.04 [0.84, 1.3]
7 studies · 996 participants
Low

H2 receptor antagonists vs placebo or no prophylaxis

Nosocomial pneumonia · people admitted to intensive care units

H2 receptor antagonists showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review

Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
RR 1.12 [0.85, 1.48]
8 studies · 945 participants
Low