What do systematic reviews say?

Allopurinol vs placebo

Allopurinol showed no clear difference in no episodes of acute pouchitis compared with placebo (low certainty).

• Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis 2019 · Cochrane Headline outcomes only
  RR 1.43 [0.66, 3.11]
  1 study · 184 participants
  Low