Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 60 findings · 6 reviews

No studies found 12 · 20%GRADE not reported 0 · 0%Very low 17 · 28.3%Low 14 · 23.3%Moderate 16 · 26.7%High 1 · 1.7%

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ full course · neonates with sepsis

It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ injectable antibiotic · neonates with sepsis

Comparison 1: route of antibiotic probably leads to lower neonatal mortality ‐ injectable antibiotic compared with standard care (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Late neonatal mortality ‐ Group counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes late neonatal mortality ‐ Group counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality ‐ One‐to‐one counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes neonatal mortality ‐ One‐to‐one counselling compared with control (very low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ One‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to higher early neonatal mortality ‐ One‐to‐one counselling compared with control (low certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality · developing countries

Community health educational one‐to‐one and group and both… showed no clear difference in neonatal mortality ‐ Both group and one‐to‐one counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Late neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes late neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review