Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Early treatment vs expectant management

NEC ≥ stage II · preterm infants

Early treatment showed no clear difference in necrotizing enterocolitis (NEC; stage 2 or greater) compared with expectant management (low certainty).

1 finding from 1 review

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
RR 2.34 [0.86, 6.41]
5 studies · 473 participants
Low

Very early treatment vs expectant management

NEC ≥ stage II · preterm infants

Very early treatment showed no clear difference in necrotizing enterocolitis (NEC; stage 2 or greater) compared with expectant management (moderate certainty).

1 finding from 1 review

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
RR 1.08 [0.53, 2.21]
5 studies · 332 participants
Moderate