Azoles vs placebo
Mycological cure · participants with confirmed toenail onychomycosis
Azole leads to higher mycological cure compared with placebo (high certainty).
1 finding from 1 review
- RR 5.86 [3.23, 10.62]9 studies · 3440 participantsHigh
Findings
What do systematic reviews say?
6 questions · 6 findings · 1 reviews · Skin
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 1 · 16.7%Moderate 2 · 33.3%High 2 · 33.3%
Griseofulvin vs azole
Mycological cure · participants with confirmed toenail onychomycosis
Griseofulvin showed no clear difference in mycological cure compared with azole (moderate certainty).
1 finding from 1 review
- RR 0.87 [0.5, 1.51]5 studies · 222 participantsModerate
Azoles vs terbinafine
Mycological cure · participants with confirmed toenail onychomycosis
Azole probably leads to lower mycological cure compared with terbinafine (moderate certainty).
1 finding from 1 review
- RR 0.77 [0.68, 0.88]17 studies · 2544 participantsModerate
Griseofulvin vs terbinafine
Mycological cure · participants with confirmed toenail onychomycosis
Griseofulvin may leads to lower mycological cure compared with terbinafine (low certainty).
1 finding from 1 review
- RR 0.64 [0.46, 0.9]5 studies · 465 participantsLow
Combination terbinafine plus azole vs terbinafine
Mycological cure · participants with confirmed toenail onychomycosis
It is very uncertain whether combination terbinafine plus azole changes mycological cure compared with terbinafine monotherapy (very low certainty).
1 finding from 1 review
- RR 1.41 [1.08, 1.83]1 study · 176 participantsVery low
Complete cure and adverse events for terbinafine vs placebo
Mycological cure · participants with confirmed toenail onychomycosis
Terbinafine leads to higher mycological cure compared with placebo (high certainty).
1 finding from 1 review
- RR 4.53 [2.47, 8.33]8 studies · 1006 participantsHigh