Findings

What do systematic reviews say?

5 questions · 6 findings · 3 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 3 · 50%Very low 2 · 33.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
HR 0.83 [0.64, 1.07]
1 study
GRADE not reported

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
HR 0.67 [0.35, 1.28]
1 study
GRADE not reported

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Total mortality · Adults with oral cavity cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Total mortality: 2 trials reported HR but could not be pooled (different surgical procedures); neither indicated a difference (BHNCSG 1998 HR 1.14, 0.70 to 1.86; Bier 1994 HR 0.87, 0.41 to 1.83); 252 participants (2…
2 studies · 252 participants
Very low

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
5 years
HR 0.57 [0.29, 1.11]
1 study · 104 participants
Very low

Visual screening (oral visual inspection) by trained health workers vs No screening

Oral cancer mortality (disease-specific) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…

Visual screening (oral visual inspection) by trained health workers showed no clear difference in oral cancer mortality (disease-specific) compared with no screening (low certainty).

2 findings from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
15-year follow-up
RR 0.88 [0.69, 1.12]
1 study · 191873 participants
Low
Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
15-year follow-up · High-risk individuals (tobacco and/or alcohol users)
RR 0.76 [0.60, 0.97]
1 study
GRADE not reported