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Evidence found and GRADE certainty

4 questions · 6 findings · 2 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 5 · 83.3%Very low 0 · 0%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

All cause mortality · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Mortality (all cause) · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for Mortality (all cause) (Vitamin D2, general population): RR 1.04 (95% CI 0.97 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

2 findings from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Cardiovascular mortality · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease mortality: RR 0.55 (95% CI 0.36 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Visual screening (oral visual inspection) by trained health workers vs No screening

Oral cancer mortality (disease-specific) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…

Visual screening (oral visual inspection) by trained health workers showed no clear difference in oral cancer mortality (disease-specific) compared with no screening (low certainty).

2 findings from 1 review