Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · All outcomes

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No studies found 1 · 16.7%GRADE not reported 2 · 33.3%Very low 1 · 16.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Mortality rate and cause of death · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Surgery plus radiotherapy vs Radiotherapy alone

Total mortality · Adults with oral cavity or oropharyngeal cancer

It is very uncertain whether surgery plus radiotherapy changes total mortality compared with radiotherapy alone (very low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.24 [0.10, 0.59]
1 study · 35 participants
Very low

Surgery vs Radiotherapy alone

Total mortality · Adults with oropharyngeal cancer

Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.83 [0.09, 7.46]
1 study · 68 participants
Low

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
HR 0.83 [0.64, 1.07]
1 study
GRADE not reported

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
HR 0.67 [0.35, 1.28]
1 study
GRADE not reported

Surgery vs Radiotherapy alone

Disease-free survival · Adults with oropharyngeal cancer

Surgery showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with radiotherapy alone (low certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 1.07 [0.27, 4.22]
1 study · 68 participants
Low