Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Dementia and Cognitive Improvement

No studies found 1 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 50%High 1 · 25%

All‐cause mortality · cognitively healthy people in late life

Aspirin leads to higher mortality compared with placebo (high certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.14 [1.01, 1.28]
1 study · 19114 participants
High

All‐cause mortality · cognitively healthy people in late life

Other NSAIDs showed no clear difference in mortality compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.37 [0.78, 2.43]
1 study · 2528 participants
Moderate

All‐cause mortality · older people with age‐related memory loss

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mortality · people with MCI

The intervention showed no clear difference in mortality (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.62 [0.85, 3.05]
1 study · 1457 participants
Moderate