Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 36 findings · 11 reviews

No studies found 12 · 33.3%GRADE not reported 1 · 2.8%Very low 12 · 33.3%Low 8 · 22.2%Moderate 3 · 8.3%High 0 · 0%

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Maintenance ASM vs no maintenance ASM after achieving seizure control

Mortality before hospital discharge · neonates with clinically diagnosed seizures

Summary of findings table ‐ Maintenance ASM showed no clear difference in mortality before hospital discharge compared with no maintenance ASM after achieving seizure control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Treatment of clinical and electrographic seizures vs treatment of clinical seizures alone

Mortality before hospital discharge · neonates

Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in mortality before hospital discharge compared with treatment of clinical seizures alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Lignocaine vs benzodiazepines

Mortality or neurodevelopmental disability at 12 months · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Lignocaine changes mortality or neurodevelopmental disability at 12 months compared with benzodiazepines (very low certainty).

1 finding from 1 review