Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Recombinant follicle stimulating hormone vs urinary‐derived gonadotrophins

Miscarriage · ovulation induction in polycystic ovarian syndrome

Recombinant follicle stimulating hormone showed no clear difference in miscarriage rate per woman compared with urinary‐derived gonadotrophins (low certainty).

1 finding from 1 review

Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
RR 1.2 [0.71, 2.04]
7 studies · 970 participants
Low

Human menopausal gonadotrophin or highly purified human menopausal gonadotrophin vs urinary follicle stimulating hormone

Miscarriage · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes miscarriage rate per woman compared with urinary follicle stimulating hormone (very low certainty).

1 finding from 1 review

Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
RR 0.33 [0.06, 1.97]
2 studies · 98 participants
Very low

Metformin combined with clomiphene citrate vs clomiphene

Miscarriage · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.35 [0.91, 2]
10 studies · 1206 participants
Low

Metformin vs placebo or no treatment

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.08 [0.5, 2.35]
4 studies · 748 participants
Low

Metformin vs clomiphene

Miscarriage rate per woman aParticipants with BMI < 30 kg/2 · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI < 30 kg/2 compared with clomiphene citrate (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.51 [0.62, 3.71]
4 studies · 281 participants
Low

Metformin vs clomiphene

Miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.61 [0.27, 1.38]
2 studies · 500 participants
Low