Findings

What do systematic reviews say?

2 questions · 3 findings · 2 reviews · Skin

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

Methotrexate · people with chronic plaque psoriasis

Any systemic treatment may leads to higher methotrexate compared with placebo (low certainty).

2 findings from 1 review

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis 2020 · Cochrane Headline outcomes only
RR 9.78 [7.15, 13.37]
3 studies · 318 participants
Low
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis 2020 · Cochrane Headline outcomes only
RR 0.43 [0.2, 0.95]
3 studies · 319 participants
Moderate

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 1.15 [0.01, 151.54]
1 study · 50 participants
Very low