Hydroxyurea vs no hydroxyureaMeasures of ANC · people with sickle cell disease1 finding from 1 reviewHydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 44 participantsVery low
Hydroxyurea vs observationMeasures of ANC · adults and children with sickle cell disease and an increased risk of stroke1 finding from 1 reviewHydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 22 participantsVery low
Hydroxyurea vs placeboMeasures of ANC · people with sickle cell disease1 finding from 1 reviewHydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 724 participantsModerate
Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelationMeasures of ANC · adults and children with sickle cell disease and an increased risk of stroke1 finding from 1 reviewHydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 254 participantsModerate