Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

27 questions · 39 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 6 · 15.4%Very low 22 · 56.4%Low 10 · 25.6%Moderate 1 · 2.6%High 0 · 0%

Intralesional betamethasone vs placebo

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…
    1 study · 180 participants
    GRADE not reported

Tongue depressor stretches (physiotherapy) vs Intralesional steroid plus hyaluronidase injections

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether tongue depressor stretches (physiotherapy) changes maximal mouth opening (interincisal distance) compared with intralesional steroid plus hyaluronidase injections (very low certainty).

1 finding from 1 review

Hydrocortisone plus hyaluronidase (intralesional) vs Intralesional steroid plus hyaluronidase injections

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Singh 2010 (hydrocortisone+hyaluronidase 50 vs triamcinolone+hyaluronidase 50): mouth opening reported categorically (trismus) rather than as continuous data, precluding quantitative analysis; authors found no…
    1 study · 100 participants
    GRADE not reported

Antioxidant capsules vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Sudarshan 2012 (topical aloe vera 10 vs antioxidant capsules 10): reported improvement in interincisal distance but no baseline data, so change could not be determined; excluded from meta-analysis.
    1 study · 20 participants
    GRADE not reported

Pentoxifylline vs Spirulina

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline may leads to lower maximal mouth opening (interincisal distance) compared with spirulina (low certainty).

1 finding from 1 review

Hydrocortisone plus hyaluronidase (intralesional) vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether hydrocortisone plus hyaluronidase (intralesional) changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

1 finding from 1 review

Intralesional triamcinolone vs Intralesional salvianolic acid B

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional triamcinolone changes maximal mouth opening (interincisal distance) compared with intralesional salvianolic acid B (very low certainty).

1 finding from 1 review