What do systematic reviews say?

Magnesium sulphate vs placebo (outcomes

Magnesium sulphate showed no clear difference in severe maternal outcome potentially related to treatment (death,… compared with placebo (outcomes (low certainty).

• Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus 2024 · Cochrane Headline outcomes only
  RR 0.32 [0.01, 7.92]
  4 studies · 5300 participants
  Low

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes maternal death compared with standard‐dose regimens (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 0.28 [0.03, 2.58]
  1 study · 72 participants
  Very low

Treatment of eclampsia: IV maintenance vs standard IM maintenance regimen

It is very uncertain whether treatment of eclampsia: IV maintenance changes maternal death compared with standard IM maintenance regimen (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 0.35 [0.04, 3.27]
  1 study · 137 participants
  Very low

Treatment of eclampsia: duration of postpartum maintenance regimen: short vs 24 hours after delivery

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: loading dose alone vs loading dose + maintenance regimen

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 462 participants
  Very low

Prevention of eclampsia: IV maintenance vs standard IM maintenance regimen

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: short vs standard maintenance regimen (subgroups by type of short regimen)

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Treatment of eclampsia: loading dose alone vs loading dose + maintenance regimen

It is very uncertain whether treatment of eclampsia: loading dose alone changes maternal death compared with loading dose plus maintenance dose regimen (very low certainty).

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  RR 2.59 [0.11, 61.75]
  1 study · 80 participants
  Very low

Prevention of eclampsia: higher vs lower IV maintenance regimen

The review found no eligible studies for this question.

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prevention of eclampsia: IV maintenance vs a serial IV bolus regimen

• Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 200 participants
  Very low