What do systematic reviews say?

Citrate vs unfractionated heparin

Citrate probably leads to lower major bleeding compared with unfractionated heparin (moderate certainty).

• Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement… 2020 · Cochrane Headline outcomes only
  RR 0.22 [0.08, 0.62]
  7 studies · 535 participants
  Moderate