Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Vascular

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No studies found 0 · 0%GRADE not reported 1 · 50%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

ASA with LMWH vs placebo or IVIG

Bleeding ‐ major (bleeding requiring transfusion) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ major (bleeding requiring transfusion) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
RR 9 [0.49, 164.76]
1 study · 180 participants
Moderate

ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH

Bleeding ‐ major/excessive · people with antiphospholipid antibodies and no history of thrombosis

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 120 participants
GRADE not reported