Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

6‐Mercaptopurine vs methotrexate

Maintenance of remission · maintenance of remission in Crohn's disease

It is very uncertain whether 6‐Mercaptopurine changes maintenance of remission compared with methotrexate (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.94 [0.47, 1.85]
1 study · 31 participants
Very low

Azathioprine or 6‐mercaptopurine vs mesalazine or sulfasalazine

Maintenance of remission · maintenance of remission in Crohn's disease

Azathioprine or 6‐mercaptopurine showed no clear difference in maintenance of remission compared with mesalazine or sulfasalazine (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.09 [0.88, 1.34]
2 studies · 166 participants
Low

Azathioprine or 6‐mercaptopurine vs placebo

Maintenance of remission · maintenance of remission in Crohn's disease

Azathioprine or 6‐mercaptopurine may leads to higher maintenance of remission (sensitivity analysis excluding Candy 1995) compared with placebo (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.19 [1.05, 1.34]
6 studies · 489 participants
Low

Azathioprine + infliximab vs infliximab

Maintenance of remission · maintenance of remission in Crohn's disease

It is very uncertain whether azathioprine and infliximab changes maintenance of remission compared with infliximab (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.02 [0.74, 1.4]
1 study · 36 participants
Very low

Azathioprine vs budesonide

Maintenance of remission · maintenance of remission in Crohn's disease

Azathioprine may leads to higher maintenance of remission compared with budesonide (low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 1.65 [1.13, 2.42]
1 study · 77 participants
Low