Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 3 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Before cavity sealing vs After cavity sealing · MMP-2 expression/activity
  Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
  60 days after cavity sealing
  no estimate extracted
  2 studies · 48 participants
  Very low
Direct match · question page
- Carious dentin before cavity sealing vs Carious dentin after cavity sealing · MMP-2 expression/activity
  Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
  Before vs after sealing (Kuhn 2016: 60 days follow-up) · Ex vivo (extracted teeth / clinical carious or biofilm samples)
  There is no difference of MMP-2 expression/activity before and after cavity sealing, although the evidence is very uncertain.
  2 studies · 48 participants
  Very low
Related · question page
- Irradiated carious dentin vs Non-irradiated carious dentin · MMP-2 expression/activity
  Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
  Ex vivo (extracted teeth / clinical carious or biofilm samples)
  No significant difference in MMP-2 (gelatinase) expression or activity between irradiated and non-irradiated groups (Gomes-Silva et al., 2017a); GRADE not separately applied to this comparison.
  1 study · 36 participants
  GRADE not reported
Related · question page
- Irradiated carious dentin vs Non-irradiated carious dentin · MMP-20 expression/activity
  Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
  Ex vivo (extracted teeth / clinical carious or biofilm samples)
  There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
  1 study · 36 participants
  Very low

Irradiated carious dentin vs Non-irradiated carious dentin

MMP-2 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)

MMP-2 showed no difference between irradiated and non-irradiated carious dentin (one study; ungraded).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
No significant difference in MMP-2 (gelatinase) expression or activity between irradiated and non-irradiated groups (Gomes-Silva et al., 2017a); GRADE not separately applied to this comparison.
1 study · 36 participants
GRADE not reported

Irradiated carious dentin vs Non-irradiated carious dentin

MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)

MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low

Carious dentin before cavity sealing vs Carious dentin after cavity sealing

MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities

MMP-2 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Before vs after sealing (Kuhn 2016: 60 days follow-up) · Ex vivo (extracted teeth / clinical carious or biofilm samples)
There is no difference of MMP-2 expression/activity before and after cavity sealing, although the evidence is very uncertain.
2 studies · 48 participants
Very low

Before cavity sealing vs After cavity sealing

MMP-2 expression/activity · Human carious dentin

No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
60 days after cavity sealing
no estimate extracted
2 studies · 48 participants
Very low