Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

MMP-13 presence/activity · Human ex vivo carious dentin

MMP-13 may be increased in root compared with coronal carious dentin, but the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-13 may be increased in root caries when compared to coronal, but the evidence is very uncertain; no MMP-13 activity observed in the crown region by western blot (Yeon Lee et al., 2013).
1 study · 7 participants
Very low

MMP-13 presence/activity · Human coronal carious dentin and sound dentin

MMP-13 may be increased in carious dentin compared with sound dentin (very low certainty).

1 finding from 1 review

MMP-13 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions

MMP-13 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-13 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Loreto et al., 2014: more in coronal caries, p<0.05).
1 study · 13 participants
Very low