Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Epilepsy

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 25%High 3 · 75%

Intervention not reported

Lack of efficacy · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 388 participants
High

Intervention not reported

Lack of efficacy · adults and children with focal seizures

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2098 participants
High

Intervention not reported

Lack of efficacy · adults and children with generalised tonic‐clonic seizures with or without other seizure types

1 finding from 1 review

Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 405 participants
High

Oxcarbazepine vs phenytoin

Time to treatment failure due to lack of efficacy All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure due to lack of efficacy All participants… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.17 [0.31, 4.35]
2 studies · 480 participants
Moderate