What do systematic reviews say?

Intravenous midazolam vs intravenous diazepam

Summary of findings ‐ Intravenous midazolam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 7.95]
  1 study · 80 participants
  Moderate

Intravenous midazolam vs intravenous lorazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  High

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 120 participants
  High

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  High

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Low