What do systematic reviews say?

41 questions · 62 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 1 · 1.6%Very low 3 · 4.8%Low 17 · 27.4%Moderate 41 · 66.1%High 0 · 0%

Flavonoids (e.g., quercetin, proanthocyanidin) vs Mesoporous silica (SiO2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Flavonoids vs Silica showed no significant difference in 24 h bond strength (MD 3.764, 95% CI -5.241 to 12.769; Moderate certainty).

1 finding from 1 review

Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes
24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Self-Etch + chemical ACAD
MD 3.764 [-5.241, 12.769]
0 studies
Moderate