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Evidence found and GRADE certainty

41 questions · 62 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 1 · 1.6%Very low 3 · 4.8%Low 17 · 27.4%Moderate 41 · 66.1%High 0 · 0%

Calcium-based agent vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Calcium vs Fluorine showed no significant difference in 24 h bond strength (MD -0.523, 95% CI -5.404 to 4.358; Low certainty).

1 finding from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Hydroxyapatite (e.g., nano-HAp)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + chemical ACAD protocol network, Peptide vs HAp showed no significant difference in 24 h bond strength (MD -0.288, 95% CI -7.988 to 7.411; Very Low certainty).

2 findings from 1 review

Hydroxyapatite (e.g., nano-HAp) vs HEMA/EGDMA-based desensitizer

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs HEMA showed no significant difference in 24 h bond strength (MD -4.815, 95% CI -10.709 to 1.079; Moderate certainty).

1 finding from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids showed 12.771 MPa lower 24 h bond strength than Calcium Phosphate (MD -12.771, 95% CI -20.538 to -5.003; Moderate certainty).

2 findings from 1 review

Calcium phosphate vs control

Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin

Calcium phosphate minus Control was -21.209 MPa (95% CI -25.954 to -16.463) at 24 h.

2 findings from 1 review

HEMA/EGDMA-based desensitizer vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Calcium showed no significant difference in 24 h bond strength (MD 3.023, 95% CI -3.815 to 9.861; Moderate certainty).

1 finding from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs HEMA/EGDMA-based desensitizer

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs HEMA showed no significant difference in 24 h bond strength (MD -0.369, 95% CI -6.728 to 5.990; Low certainty).

1 finding from 1 review

HEMA/EGDMA-based desensitizer vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Calcium Phosphate showed no significant difference in 24 h bond strength (MD 0.360, 95% CI -5.589 to 6.309; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + chemical ACAD protocol network, HAp vs Fluorine showed no significant difference in 24 h bond strength (MD 4.960, 95% CI -1.806 to 11.727; Low certainty).

2 findings from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs HEMA/EGDMA-based desensitizer

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Flavonoids vs HEMA showed no significant difference in 24 h bond strength (MD 2.705, 95% CI -5.654 to 11.063; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Mesoporous silica (SiO2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs Silica showed no significant difference in 24 h bond strength (MD -3.756, 95% CI -10.536 to 3.024; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp showed 4.455 MPa lower 24 h bond strength than Calcium Phosphate (MD -4.455, 95% CI -8.857 to -0.053; Moderate certainty).

2 findings from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Flavonoids (e.g., quercetin, proanthocyanidin)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + biological ACAD protocol network, Peptide showed 9.857 MPa higher 24 h bond strength than Flavonoids (MD 9.857, 95% CI 2.588 to 17.126; Moderate certainty).

2 findings from 1 review

Mesoporous silica (SiO2) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Calcium Phosphate showed no significant difference in 24 h bond strength (MD -0.699, 95% CI -7.633 to 6.234; Moderate certainty).

1 finding from 1 review

HEMA/EGDMA-based desensitizer vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Fluorine showed no significant difference in 24 h bond strength (MD 2.500, 95% CI -2.603 to 7.603; Low certainty).

1 finding from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Flavonoids vs Calcium showed no significant difference in 24 h bond strength (MD 5.728, 95% CI -2.442 to 13.897; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Flavonoids (e.g., quercetin, proanthocyanidin)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp showed 7.520 MPa lower 24 h bond strength than Flavonoids (MD -7.520, 95% CI -14.758 to -0.281; Moderate certainty).

1 finding from 1 review

Mesoporous silica (SiO2) vs HEMA/EGDMA-based desensitizer

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs HEMA showed no significant difference in 24 h bond strength (MD -1.059, 95% CI -9.024 to 6.906; Moderate certainty).

1 finding from 1 review