Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews · Kidney and Transplant

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

Angiotensin receptor blockers (ARBs) vs angiotensin‐converting enzyme inhibitors (ACEis)

Hyperkalaemia · patients receiving PD

Angiotensin receptor blockers (ARBs) showed no clear difference in hyperkalaemia compared with angiotensin‐converting enzyme inhibitors (ACEis) (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers for preserving residual kidney function in… 2014 · Cochrane Headline outcomes only
RR 1.23 [0.35, 4.4]
2 studies · 144 participants
Moderate

Aldosterone antagonists vs diuretics

Hyperkalaemia · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

Hyperkalaemia · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs placebo or usual care

Hyperkalaemia · proteinuric CKD

Aldosterone antagonists probably leads to higher hyperkalaemia compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 2.17 [1.47, 3.22]
17 studies · 3001 participants
Moderate

Aldosterone antagonists vs ACEi or ACEi plus ARB

Hyperkalaemia · proteinuric chronic kidney disease

Aldosterone antagonists showed no clear difference in hyperkalaemia compared with ACEi or ACEi plus ARB (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 1.62 [0.66, 3.95]
2 studies · 500 participants
Low

Aldosterone antagonists vs nitrate

Hyperkalaemia · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Hyperkalaemia · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in hyperkalaemia compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 0.89 [0.45, 1.77]
1 study · 1023 participants
Low