Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 4 reviews

No studies found 3 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 44.4%Moderate 1 · 11.1%High 1 · 11.1%

Mineralocorticoid receptor antagonists (MRAs) vs placebo or no treatment

Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction

Mineralocorticoid receptor antagonists (MRAs) leads to higher hyperkalaemia compared with placebo or no treatment (high certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Hyperkalaemia · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in hyperkalaemia compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review