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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Hepato-Biliary

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Hepatotoxicity · people with paracetamol (acetaminophen) overdose

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

1 finding from 1 review

Cysteamine vs methionine (randomised trials)

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).

1 finding from 1 review

Cysteamine vs no intervention

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).

1 finding from 1 review