Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)
GtfB/C and F-ATPase activity · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry proanthocyanidins downregulate GtfB/C and F-ATPase activity of S. mutans (5 studies; ungraded).
1 finding from 1 review
- Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomesin vitro (laboratory)Cranberry PAC reduced extracellular polysaccharides 35-40% and inhibited GtfB 40-70% (Koo); decreased EPS formation (Philip 2019); inhibited F-ATPase up to 85% and GtfB up to 70% (Duarte); F-ATPase 18-33% and GtfB…5 studiesGRADE not reported