It is very uncertain whether comparison 1: 5HT1A partial agonists changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
It is very uncertain whether comparison 4: antipsychotics changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
Comparison 5: benzodiazepines may leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).
It is very uncertain whether comparison 6: beta‐blockers changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
Comparison 7: MAOIs may leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).
It is very uncertain whether comparison 8: NARIs changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
It is very uncertain whether comparison 9: NaSSAs changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
Comparison 10: RIMAs may leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).
Comparison 2: anticonvulsants/GABAs probably leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).
Comparison 12: SNRIs showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).
It is very uncertain whether comparison 13: SSRIs changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
Comparison 14: GW876008 showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).
It is very uncertain whether comparison 15: NK1 receptor antagonist GR205171 changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).
Comparison 3: anticonvulsant levetiracetam showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).
The review found no eligible studies for this question.
Comparison 6: SSRIs probably leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (moderate certainty).
Comparison 7: TCAs may leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (low certainty).
It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).
The review found no eligible studies for this question.
Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).