Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Acute Respiratory Infections

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%

Topical prophylaxis vs no topical prophylaxis

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in gastrointestinal adverse events compared with no topical prophylaxis (low certainty).

1 finding from 1 review

Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical… 2021 · Cochrane Headline outcomes only
RR 2.78 [0.26, 29.5]
3 studies · 1859 participants
Low

Topical plus systemic prophylaxis vs placebo or no treatment

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in gastrointestinal adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical… 2021 · Cochrane Headline outcomes only
RR 1.08 [0.57, 2.04]
6 studies · 2637 participants
Low