Findings

What do systematic reviews say?

22 questions · 22 findings · 6 reviews · Neuromuscular

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No studies found 4 · 18.2%GRADE not reported 1 · 4.5%Very low 14 · 63.6%Low 1 · 4.5%Moderate 2 · 9.1%High 0 · 0%

Ascorbic acid vs placebo

Health‐related quality of life (mental) · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Moderate

Ascorbic acid vs placebo

Health‐related quality of life (physical) · people with fatigue in peripheral neuropathy

1 finding from 1 review

Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 400 participants
Moderate

Intervention not reported

Function · participants with CTEV at initial presentation

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2 participants
GRADE not reported

Intervention not reported

Function · participants with relapsed or recurrent CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Function · participants with neglected CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Function ‐ · participants with CTEV (type of case (i.e. whether initial presentation or relapsed) not specified)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Function · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lisinopril (0.7 mg/kg daily) vs losartan (0.7 mg/kg daily)

Cardiac function · patients with established cardiomyopathy in DMD

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Growth hormone (0.23 mg/kg/week for DMD and 0.07 mg/kg/week in BMD SC injection) vs placebo

Change in Ejection fraction (%) · people with DMD or BMD (ages not stated)

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Acupuncture vs ibuprofen

Functional status, short‐term · carpal tunnel syndrome

1 finding from 1 review

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Very low

Idebenone vs placebo

Change in Ejection fraction (%) · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Change in cardiac function: number of patients with EF < 45% · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

It is very uncertain whether prophylactic perindopril (2 mg to 4 mg daily) changes change in cardiac function: number of patients with EF < 45% compared with placebo (very low certainty).

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.77]
1 study · 57 participants
Very low

Idebenone vs placebo

Change in cardiac function (change in fractional shortening) · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Electroacupuncture plus night splints vs night splints alone

Functional status, long‐term · carpal tunnel syndrome

1 finding from 1 review

Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 181 participants
Low

Eplerenone (25 mg daily) vs placebo

Change in Ejection fraction (%) · boys with DMD and left ventricular ejection fraction 45% or more

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Eplerenone (25 mg daily) vs placebo

Change in cardiac function: change (decline) from baseline in left ventricular strain · boys with DMD and left ventricular ejection fraction 45% or more

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Idebenone vs placebo

Change in cardiac function (change in systolic radial strain rate LV inferolateral wall) · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Idebenone vs placebo

Change in cardiac function (change in peak systolic radial strain in LV lateral wall segments) · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD

1 finding from 1 review

Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X‐linked… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Surgery for Bell's palsy vs medical treatment (oral prednisolone) or no treatment

Complete recovery of facial nerve function at 12 months Defined as: complete recovery HB grade I. · Bell's palsy

It is very uncertain whether surgery for Bell's palsy changes complete recovery of facial nerve function at 12 months Defined as:… compared with medical treatment (oral prednisolone) or no treatment (very low certainty).

1 finding from 1 review

Surgical interventions for the early management of Bell's palsy 2021 · Cochrane Headline outcomes only
RR 0.76
2 studies · 57 participants
Very low

Early surgery vs late surgery

Complete recovery of facial nerve function at 12 months Defined as: complete recovery HB grade I. · Bell's palsy

It is very uncertain whether early surgery changes complete recovery of facial nerve function at 12 months Defined as:… compared with late surgery (very low certainty).

1 finding from 1 review

Surgical interventions for the early management of Bell's palsy 2021 · Cochrane Headline outcomes only
RR 0.47 [0.03, 6.6]
1 study · 26 participants
Very low